Few diseases conjure up as much dread as Ebola hemorrhagic fever. If you’re tired of watching sitcoms and romantic comedies, take a look at “Outbreak,” a 1995 film with a stellar cast. It explores the ethical dilemma of a government that faces the decision whether to annihilate a small town where there is an outbreak of a new airborne mutant of Ebola with a mortality of close to 100% in order to prevent escape into the general population with millions of deaths or just try to contain the virus and hope for the best. The science is a bit speculative but the basic premise is more or less believable. The action, including some of the helicopter flying, is almost unbelievable.
Ebola has been the subject of a number of good books including “Ebola” by William Close MD, father of the actress Glenn Close, who was personal physician to Zaire’s infamous President Mobutu. He was a first-hand witness to the original human outbreak originating in the Belgian Catholic Yambuku Mission Hospital. Of 318 cases, 280 died (88%). The use of unsterilized needles and syringes was blamed for the rapid spread but person-to-person spread also occurred in those with close contact with patients alive or deceased.
Ebola and the related filovirus, Marburg, live in monkeys of various species and only rarely jump into humans. Fortunately. Since mortality is still on the order of 50% or more. Genetically engineering these viruses to produce a bioweapon is a distinct possibility. As we saw with the anthrax attack, there are enough adequately trained scientists lying around to do this if one of them should lose his/her grip on basic humanity. This might be especially true of Russian scientists who worked on the very extensive biological warfare program that went on in the Soviet Union up through the tenures of Gorbachev and Yeltsin and who lost their employment after the national collapse.
If you’re sick of counting sheep at night, you might try counting all the ways some madman might come up with to do us all in. Bugs, nukes, poisons, etc. Or you could think of all the ways chocolate has been made irresistible. As for me . . . .
Gordon Short, MD
28 Mar 2014
Did you ever wonder what the population of North and South America was before Columbus made his big “discovery”? As Charles C. Mann shows in his book “1491,” there is a wide diversion of opinions. The “Low Counters” estimate about 10 million while the “High Counters” guess it is more like 100 million. Why the high level of uncertainty? Seems native Americans – Aztecs, Mayans, Incas, Iroquois, Cherokees et alia – saw no need for taking censuses. Only when the Spanish arrived did the idea of taking body counts of the living become accepted.
And while the Spaniards certainly knew how to count, what they were counting were those who remained after smallpox, measles, influenza and other pandemics had decimated the various populations they were estimating. The idea that the western hemisphere was an empty continent waiting to be occupied by needy Europeans has been laid to rest along with the millions of native Americans who were killed off in short order by European diseases, particularly smallpox. In 1542 Bartolome de Las Casas, Spanish historian, Dominican friar, and American explorer, said that the Americas were so thick with people “that it looked as if God has placed all of or the greater part of the entire human race in these countries.” (Mann)
Zinnser, in his delightful book, “Rats, Lice and History,” comments on the relative unimportance of generals as compared with microbes. The outcome of more campaigns was determined by epidemic pathogens than by the brilliance of generals. How else could a piddly number of conquistadors and colonists have “opened” up the Americas for settlement and exploitation?
Although the science is disputed, it is not unreasonable to believe that the native Americans attempted to upstage the European invaders – both human and microbial – and their “Small Pox” by exporting back to Europe the “Great Pox.” (Syphilis, in case you didn’t know) Poetic justice? You decide.
Gordon Short, MD
7 Apr 2104
Now there’s a title to arouse one’s curiosity.
The training of the immune system so that it can distinguish “self” from “non-self” is something we take for granted. Maybe we shouldn’t. It begins to appear that for many, if not all people, exposure to worms in early life is a significant part of that training. Without it we may end up with autoimmune diseases such as Crohn’s, asthma, autism, MS, etc.
Many patients with Crohn’s disease are now being treated successfully with worms such as the whipworm, Trichuris trichiura. It’s a long story but excitingly told by Rob Dunn in “The Wild Life of our Bodies” and by Moises Velasquez-Manoff in “An Epidemic of Absence.” Evolution has a curious bag of tricks and we would do well to pay attention to the entire ecosystem of which we are only one small part. That includes all the microbes we are so familiar with but also our helminth friends that we tend to think so revolting. Maybe our exquisite public health and sanitation systems have given us a back-handed slap by eliminating these “parasites.”
Have you taken a worm to lunch lately? (They don’t eat very much.)
Gordon Short, MD
In the book of Samuel in the Old Testament is the following text: “But the hand of the Lord was heavy upon them of Ashdod, and he destroyed them, and smote them with emerods, even Ashdod and the coasts thereof.” 1 Samuel 5:6 (KJV)
What are Biblical “emerods” (KJV)? “Hemorrhoids” as in some other translations? “Tumors” as in more recent translations? Or buboes?
Most people know about the Black Death, the plague that killed a third to a half of the population of Europe in a few years around 1350 AD. But how many know of the plague among the Philistines about 1320 BC? In 1 Samuel 5 & 6 there is a description of a plague of swellings in the groins of the victims (“they had emerods in their secret parts”). When the Philistines interpreted the plague as a result of their angering the God of the Israelites by their capturing of the Ark of the Covenant, the Philistines determined to send the Ark back with a guilt offering consisting of five gold “emerods” and five gold rats. Obviously they associated rats with the plague which certainly suggests that this was indeed bubonic plague.
Now if only they had known of the rat fleas, they might have sent an offering of five gold fleas instead of the rats and saved themselves considerable gold!
Gordon Short, MD